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Antibody Product Overview
| ELK.No | ES1831 |
| Product name | Calpain 11 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | CAPN11; Calpain-11; Calcium-activated neutral proteinase 11; CANP 11 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 11131 |
| Human Swiss-Prot | Q9UMQ6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Calpain 11 |
| Fields | |
| Gene name | CAPN11 |
| Protein name | Calpain-11 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q6J756 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CAPN11. AA range:401-450 |
| Specificity | Calpain 11 Polyclonal Antibody detects endogenous levels of Calpain 11 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 81kD |
| Background | Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008], |
| Function | catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit.,tissue specificity:Highest expression in testis., |
| Subcellular location | Cytoplasmic vesicle, secretory vesicle, acrosome . |
| Expression | Highest expression in testis. |
Additional Images
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Western Blot analysis of various cells using Calpain 11 Polyclonal Antibody
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: AO-06-ES1831-50
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