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Antibody Product Overview
| ELK.No | ES18408 |
| Product name | AL2CL rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | ALS2 C-terminal-like protein |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 259173 |
| Human Swiss-Prot | Q60I27 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AL2CL |
| Fields | |
| Gene name | ALS2CL |
| Protein name | AL2CL |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 235633 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60I26 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human AL2CL AA range: 606-656 |
| Specificity | This antibody detects endogenous levels of AL2CL at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.222% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | |
| Function | function:Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.,similarity:Contains 1 VPS9 domain.,similarity:Contains 8 MORN repeats.,subcellular location:Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.,subunit:Homodimer. Forms a heteromeric complex with ALS2 (By similarity). Interacts with ALS2 and RAB5A.,tissue specificity:Expressed in heart and kidney., |
| Subcellular location | Cytoplasm . Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells. |
| Expression | Expressed in heart and kidney. |
Additional Images
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Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18408-100
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