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Antibody Product Overview
| ELK.No | ES18444 |
| Product name | AF9 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4300 |
| Human Swiss-Prot | P42568 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AF9 |
| Fields | >>Viral life cycle - HIV-1;>>Transcriptional misregulation in cancer |
| Gene name | MLLT3 AF9 YEATS3 |
| Protein name | AF9 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 70122 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | A2AM29 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human AF9 AA range: 328-378 |
| Specificity | This antibody detects endogenous levels of AF9 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.153% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | |
| Function | disease:A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with MLL/HRX. The result is a rogue activator protein.,similarity:Contains 1 YEATS domain.,subunit:Interacts with BCOR. Interacts with CBX8., |
| Subcellular location | Nucleus . Chromosome . Colocalizes with acylated histone H3 (PubMed:25417107, PubMed:27105114). Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). . |
| Expression | Enriched in undifferentiated hematopoietic stem cells in fetal liver, cord blood and bone marrow. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18444-50
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