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Antibody Product Overview
| ELK.No | ES18458 |
| Product name | ADAT3 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 113179 |
| Human Swiss-Prot | Q96EY9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ADAT3 |
| Fields | |
| Gene name | ADAT3 |
| Protein name | ADAT3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 100113398 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6PAT0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 100125374 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q561R2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human ADAT3 AA range: 295-345 |
| Specificity | This antibody detects endogenous levels of ADAT3 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 39kD |
| Observed band (KD) | |
| Background | This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016], |
| Function | caution:Val-225 is present instead of the conserved Glu which is an active site in the cytidine and deoxycytidylate deaminase family of enzymes. It is suggested that this protein may act as a regulatory subunit.,cofactor:Zinc.,function:May be involved in deamination of adenosine-34 to inosine in many tRNAs as a regulatory subunit .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily., |
| Subcellular location | nucleoplasm,cytosol, |
| Expression |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18458-100
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