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Antibody Product Overview
| ELK.No | ES18460 |
| Product name | ADAM2 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2515 |
| Human Swiss-Prot | Q99965 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ADAM2 |
| Fields | |
| Gene name | ADAM2 FTNB |
| Protein name | ADAM2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11495 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60718 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 56806 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63202 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human ADAM2 AA range: 109-159 |
| Specificity | This antibody detects endogenous levels of ADAM2 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 81kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013], |
| Function | domain:A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.,function:Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.,miscellaneous:In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.,PTM:The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.,similarity:Contains 1 disintegrin domain.,similari |
| Subcellular location | Membrane; Single-pass type I membrane protein. |
| Expression | Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18460-100
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