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Antibody Product Overview
| ELK.No | ES18463 |
| Product name | ADA11 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4185 |
| Human Swiss-Prot | O75078 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ADA11 |
| Fields | |
| Gene name | ADAM11 MDC |
| Protein name | ADA11 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11488 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9R1V4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human ADA11 AA range: 600-650 |
| Specificity | This antibody detects endogenous levels of ADA11 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.327% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016], |
| Function | disease:Rearrangements occur in breast and ovarian cancers which involve multiple exons and disrupt the coding region.,domain:A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.,function:Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed predominantly in brain. Slightly detected or not at all in other tissues., |
| Subcellular location | Membrane; Single-pass type I membrane protein. |
| Expression | Expressed predominantly in brain. Slightly detected or not at all in other tissues. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES18463-100
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