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Antibody Product Overview
| ELK.No | ES1894 |
| Product name | CD137L rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IF;ELISA |
| Other name | TNFSF9; Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8744 |
| Human Swiss-Prot | P41273 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD137L |
| Fields | >>Cytokine-cytokine receptor interaction |
| Gene name | TNFSF9 |
| Protein name | Tumor necrosis factor ligand superfamily member 9 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P41274 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80 |
| Specificity | CD137L Polyclonal Antibody detects endogenous levels of CD137L protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 23kD |
| Background | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b |
| Function | function:Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer .,tissue specificity:Expressed in brain, placenta, lung, skeletal muscle and kidney., |
| Subcellular location | Membrane; Single-pass type II membrane protein. |
| Expression | Expressed in brain, placenta, lung, skeletal muscle and kidney. |
Additional Images
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Western Blot analysis of various cells using CD137L Polyclonal Antibody diluted at 1:1000
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Western Blot analysis of HuvEc cells using CD137L Polyclonal Antibody diluted at 1:1000
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Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HUVEC cells, using TNFSF9 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES1894-50
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