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Antibody Product Overview
| ELK.No | ES1933 |
| Product name | CDC46 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | MCM5; CDC46; DNA replication licensing factor MCM5; CDC46 homolog; P1-CDC46 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4174 |
| Human Swiss-Prot | P33992 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CDC46 |
| Fields | >>DNA replication;>>Cell cycle |
| Gene name | MCM5 |
| Protein name | DNA replication licensing factor MCM5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P49718 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MCM5. AA range:21-70 |
| Specificity | CDC46 Polyclonal Antibody detects endogenous levels of CDC46 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 90kD |
| Background | The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008], |
| Function | similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain., |
| Subcellular location | Nucleus . Chromosome . Cytoplasm, cytosol . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. . |
| Expression | Cervix,Cervix carcinoma,Lymph,Placenta,Spleen,Thymus,Tongue |
Additional Images
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Western Blot analysis of various cells using CDC46 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western Blot analysis of HepG2 cells using CDC46 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Immunofluorescence analysis of HepG2 cells, using MCM5 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using MCM5 Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES1933-50
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