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Antibody Product Overview
| ELK.No | ES1979 |
| Product name | CHP2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CHP2; HCA520; Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 63928 |
| Human Swiss-Prot | O43745 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CHP2 |
| Fields | |
| Gene name | CHP2 |
| Protein name | Calcineurin B homologous protein 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9D869 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 308965 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q810D1 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHP2. AA range:101-150 |
| Specificity | CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 22kD |
| Background | This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013], |
| Function | function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death.,similarity:Contains 4 EF-hand domains.,subunit:Binds to SLC9A1/NHE1.,tissue specificity:Expressed in malignantly transformed cells but not detected in normal tissues., |
| Subcellular location | Nucleus . Cytoplasm . Cell membrane . Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. . |
| Expression | Expressed in malignantly transformed cells but not detected in normal tissues. |
Additional Images
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Western Blot analysis of various cells using CHP2 Polyclonal Antibody
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Western blot analysis of lysates from HT-29, K562, and Jurkat cells, using CHP2 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1979-100
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