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Antibody Product Overview
| ELK.No | ES1981 |
| Product name | CHST2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | CHST2; GN6ST; Carbohydrate sulfotransferase 2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; GST-2; N-acetylglucosamine 6-O-sulfotransferase 1; GlcNAc6ST-1; Gn6ST-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9435 |
| Human Swiss-Prot | Q9Y4C5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CHST2 |
| Fields | >>Glycosaminoglycan biosynthesis - keratan sulfate |
| Gene name | CHST2 |
| Protein name | Carbohydrate sulfotransferase 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q80WV3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHST2. AA range:1-50 |
| Specificity | CHST2 Polyclonal Antibody detects endogenous levels of CHST2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 58kD |
| Background | This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011], |
| Function | caution:It is uncertain whether Met-1 or Met-48 is the initiator.,function:Catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as L-selectin ligands. L-selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.,induction:Up-regulated upon cytokine activation.,online information:GlycoGene database,similarity:Belongs to the sulfotransferase 1 family. |
| Subcellular location | Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein . |
| Expression | Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. |
Additional Images
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Western Blot analysis of various cells using CHST2 Polyclonal Antibody
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Western blot analysis of lysates from A549, COLO, and Jurkat cells, using CHST2 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from K562 cells using CHST2 antibody.
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: AO-06-ES1981-50
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