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Antibody Product Overview
| ELK.No | ES1998 |
| Product name | CLIP-170 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CLIP1; CYLN1; RSN; CAP-Gly domain-containing linker protein 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-Sternberg intermediate filament-associated protein; Restin |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6249 |
| Human Swiss-Prot | P30622 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CLIP-170 |
| Fields | >>mTOR signaling pathway |
| Gene name | CLIP1 |
| Protein name | CAP-Gly domain-containing linker protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56430 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q922J3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CLIP1. AA range:1291-1340 |
| Specificity | CLIP-170 Polyclonal Antibody detects endogenous levels of CLIP-170 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 161kD |
| Background | The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011], |
| Function | function:Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.,similarity:Contains 2 CAP-Gly domains.,subcellular location:Associated with the cytoskeleton.,tissue specificity:Highly expressed in the Reed-Sternberg cells of Hodgkin's disease., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle . Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). . |
| Expression | Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. |
Additional Images
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Western Blot analysis of various cells using CLIP-170 Polyclonal Antibody
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Western Blot analysis of RAW264.7 cells using CLIP-170 Polyclonal Antibody
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Western blot analysis of lysates from HUVEC, COLO, MCF-7, HepG2, and RAW264.7 cells, using CLIP1 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES1998-50
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