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Antibody Product Overview
| ELK.No | ES2005 |
| Product name | CLP36 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | PDLIM1; CLIM1; CLP36; PDZ and LIM domain protein 1; C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9124 |
| Human Swiss-Prot | O00151 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CLP36 |
| Fields | |
| Gene name | PDLIM1 |
| Protein name | PDZ and LIM domain protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 54132 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O70400 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 54133 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P52944 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PDLIM1. AA range:61-110 |
| Specificity | CLP36 Polyclonal Antibody detects endogenous levels of CLP36 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 36kD |
| Background | This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012], |
| Function | function:Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Associates with the actin stress fibers.,subunit:Interacts with alpha-actinins 1, 2 and 4.,tissue specificity:Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Associates with actin stress fibers. . |
| Expression | Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes. |
Additional Images
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Western Blot analysis of various cells using CLP36 Polyclonal Antibody diluted at 1:1000
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Western Blot analysis of K562 cells using CLP36 Polyclonal Antibody diluted at 1:1000
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Immunofluorescence analysis of HepG2 cells, using PDLIM1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human heart tissue, using PDLIM1 Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES2005-100
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