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c-Jun (Phospho Ser249) rabbit pAb
AO-06-ES20155-50
Antibody Product Overview
| ELK.No | ES20155 |
| Product name | c-Jun (Phospho Ser249) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB; ELISA |
| Other name | Transcription factor AP-1 (Activator protein 1;AP1;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog;p39) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3725 |
| Human Swiss-Prot | P05412 |
| Source | Rabbit |
| Isotype | IgG |
| Target | c-JUN |
| Fields | >>Endocrine resistance;>>MAPK signaling pathway;>>ErbB signaling pathway;>>cAMP signaling pathway;>>Mitophagy - animal;>>Apoptosis;>>Wnt signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>Tight junction;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>TNF signaling pathway;>>Neurotrophin signaling pathway;>>GnRH signaling pathway;>>Estrogen signaling pathway;>>Oxytocin signaling pathway;>>Relaxin signaling pathway;>>Non-alcoholic fatty liver disease;>>AGE-RAGE signaling pathway in diabetic complications;>>Cocaine addiction;>>Amphetamine addiction;>>Epithelial cell signaling in Helicobacter pylori infection;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Yersinia infection;>>Leishmaniasis;>>Chagas di |
| Gene name | JUN |
| Protein name | c-Jun (Phospho Ser249); Transcription factor AP-1;jun;c-jun；AP-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16476 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P05627 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24516 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P17325 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human c-Jun (Phospho Ser249) |
| Specificity | This antibody detects endogenous levels of Human,Mouse,Rat c-Jun (Phospho Ser249) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:1000-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 39-42kD |
| Background | function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA., |
| Function | protein import into nucleus, translocation, response to reactive oxygen species, angiogenesis, blood vessel development, release of cytochrome c from mitochondria, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, vasculature development, response to molecule of bacterial origin,regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, regulation of DNA replication, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein targeting, protein import into nucleus, cellular ion homeostasis, intracellular protein transport, nucleocytoplasmic transport, apoptosis, response to oxidative stress, mitochondrion organization, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway |
| Subcellular location | Nucleus. |
| Expression | Expressed in the developing and adult prostate and prostate cancer cells. |
Additional Images
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Western Blot analysis of various,using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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: AO-06-ES20155-50
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