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Antibody Product Overview
| ELK.No | ES2040 |
| Product name | CPM rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | CPM; Carboxypeptidase M; CPM |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1368 |
| Human Swiss-Prot | P14384 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CPM |
| Fields | |
| Gene name | CPM |
| Protein name | Carboxypeptidase M |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q80V42 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CPM. AA range:71-120 |
| Specificity | CPM Polyclonal Antibody detects endogenous levels of CPM protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 51kD |
| Background | carboxypeptidase M(CPM) Homo sapiens The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Cleavage of C-terminal arginine or lysine residues from polypeptides.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by O-phenanthroline and MGTA and activated by cobalt.,function:Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.,similarity:Belongs to the peptidase M14 family., |
| Subcellular location | Cell membrane ; Lipid-anchor, GPI-anchor . |
| Expression | Liver,Lung,Placenta, |
Additional Images
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Western Blot analysis of various cells using CPM Polyclonal Antibody
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Western blot analysis of lysates from A549 cells, using CPM Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HT-29 cells using CPM antibody.
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: AO-06-ES2040-50
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