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Histone H2A (Acetyl Lys15) rabbit pAb
AO-06-ES20537-50
Antibody Product Overview
| ELK.No | ES20537 |
| Product name | Histone H2A (Acetyl Lys15) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB |
| Other name | HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p; HIST2H2AA3; H2AFO; HIST2H2AA; HIST2H2AA4; Histone H2A type 2-A; Histone H2A.2; Histone H2A/o; HIST3H2A; Histone H2A type 3;H2AK15AC |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8329/8330/8332/8336/8969/723790/8337/92815 |
| Human Swiss-Prot | P0C0S8/Q6FI13/Q7L7L0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Histone H2A |
| Fields | >>Necroptosis;>>Neutrophil extracellular trap formation;>>Alcoholism;>>Systemic lupus erythematosus |
| Gene name | HIST1H2AG/HIST1H2AI/HIST1H2AK/HIST1H2AL/HIST1H2AM/HIST2H2AA3/HIST2H2AA4/HIST3H2A |
| Protein name | Histone H2A type 1/Histone H2A type 2/Histone H2A type 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 319164/15267/319162 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | 365877/64646 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P02262/P0CC09/Q4FZT6 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthetic Peptide of Histone H2A (Acetyl Lys15) |
| Specificity | The antibody detects endogenous Histone H2A (Acetyl Lys15) protein. |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Clonality | Polyclonal |
| Dilution | WB: 1:500-1000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. |
| Concentration | |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 14kD |
| Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015], |
| Function | function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosom |
| Subcellular location | Nucleus. Chromosome. |
| Expression | Bone,Brain,Colon,Eye,Lymph,PCR rescued clones,Placenta,Sple |
Additional Images
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Western blot analysis of extracts from Hela cells, untreated (-) or treated, 1:5000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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