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Antibody Product Overview
| ELK.No | ES20863 |
| Product name | Aurora A Rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | IHC;WB |
| Other name | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6790 |
| Human Swiss-Prot | O14965 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Aurora A |
| Fields | >>Oocyte meiosis;>>Progesterone-mediated oocyte maturation |
| Gene name | AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 |
| Protein name | Aurora A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20878 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P97477 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P59241 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human Aurora A AA range: 65-115 |
| Specificity | This antibody detects endogenous levels of Aurora A at Human, Mouse,Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.20% sodium azide. |
| Clonality | Polyclonal |
| Dilution | IHC-p1:50-200 ,WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 46kD |
| Background | Aurora A(AURKA) Homo sapiens The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. |
| Function | |
| Subcellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle |
| Expression | Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. |
Additional Images
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Western blot analysis of 1)HepG2 Cell, 2) Hela Cells treated with Nocodazole using Rabbit pAb diluted at 1:2,000.
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Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES20863-100
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