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Antibody Product Overview
| ELK.No | ES20867 |
| Product name | Eif4b Rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | IHC;WB |
| Other name | Eukaryotic translation initiation factor 4B (eIF-4B) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1975 |
| Human Swiss-Prot | P23588 |
| Source | Rabbit |
| Isotype | IgG |
| Target | eIF4B |
| Fields | >>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>Proteoglycans in cancer |
| Gene name | EIF4B |
| Protein name | Eif4b |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 75705 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BGD9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human Eif4b AA range: 209-259 |
| Specificity | This antibody detects endogenous levels of Eif4b at Human, Mouse,Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.77% sodium azide. |
| Clonality | Polyclonal |
| Dilution | IHC-p1:50-200 ,WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 69kD |
| Background | cRequired for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit. |
| Function | function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit., |
| Subcellular location | cytosol,polysome,eukaryotic translation initiation factor 4F complex,dendrite,neuronal cell body, |
| Expression | Adipose tissue,Brain,Cervix carcinoma,Epithelium,Liver,Lung |
Additional Images
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Western blot analysis of 1)Hela Cell, 2) 3T3 Cell, 3)PC12 Cell Lysate using Eif4bRabbit Polyclonal Antibody diluted at 1:2,000.
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES20867-100
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