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Antibody Product Overview
| ELK.No | ES2104 |
| Product name | CYP2J2 rabbit pAb |
| Reactivity | Human;Monkey |
| Applications | WB;IHC;IF;ELISA |
| Other name | CYP2J2; Cytochrome P450 2J2; Arachidonic acid epoxygenase; CYPIIJ2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1573 |
| Human Swiss-Prot | P51589 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CYP2J2 |
| Fields | >>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>Metabolic pathways;>>Serotonergic synapse;>>Inflammatory mediator regulation of TRP channels;>>Ovarian steroidogenesis;>>Lipid and atherosclerosis |
| Gene name | CYP2J2 |
| Protein name | Cytochrome P450 2J2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2J2. AA range:231-280 |
| Specificity | CYP2J2 Polyclonal Antibody detects endogenous levels of CYP2J2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 58kD |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016], |
| Function | catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.,online information:CYP2J2 alleles,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney., |
| Subcellular location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein. |
| Expression | Highly expressed in heart, present at lower levels in liver, kidney and skeletal muscle (at protein level). |
Additional Images
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Western Blot analysis of various cells using CYP2J2 Polyclonal Antibody
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Immunofluorescence analysis of HepG2 cells, using Cytochrome P450 2J2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human heart tissue, using Cytochrome P450 2J2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from A549 and COS7 cells, using Cytochrome P450 2J2 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2104-50
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