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Antibody Product Overview
| ELK.No | ES2137 |
| Product name | D4DR rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | DRD4; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1815 |
| Human Swiss-Prot | P21917 |
| Source | Rabbit |
| Isotype | IgG |
| Target | D4DR |
| Fields | >>Neuroactive ligand-receptor interaction;>>Dopaminergic synapse |
| Gene name | DRD4 |
| Protein name | D(4) dopamine receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13491 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P51436 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25432 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P30729 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DRD4. AA range:355-404 |
| Specificity | D4DR Polyclonal Antibody detects endogenous levels of D4DR protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 48kD |
| Background | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008], |
| Function | function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CLIC6 (By similarity) and GPRASP1., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . |
| Expression | Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary. |
Additional Images
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Western Blot analysis of various cells using D4DR Polyclonal Antibody
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Western Blot analysis of K562 cells using D4DR Polyclonal Antibody
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Immunofluorescence analysis of MCF7 cells, using DRD4 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from MCF-7 and HUVEC cells, using DRD4 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2137-100
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