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Antibody Product Overview
| ELK.No | ES2194 |
| Product name | Dok-6 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC;IF;ELISA |
| Other name | DOK6; DOK5L; Docking protein 6; Downstream of tyrosine kinase 6 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 220164 |
| Human Swiss-Prot | Q6PKX4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Dok-6 |
| Fields | |
| Gene name | DOK6 |
| Protein name | Docking protein 6 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 623279 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q2MHE5 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DOK6. AA range:111-160 |
| Specificity | Dok-6 Polyclonal Antibody detects endogenous levels of Dok-6 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 43kD |
| Background | docking protein 6(DOK6) Homo sapiens DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008], |
| Function | domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.,PTM:On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.,similarity:Belongs to the DOK family. Type B subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts via its PTB domain with phosphorylated RET.,tissue specificity:Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis., |
| Subcellular location | |
| Expression | Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. |
Additional Images
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Western Blot analysis of various cells using Dok-6 Polyclonal Antibody
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Immunofluorescence analysis of A549 cells, using DOK6 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from COLO cells, using DOK6 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
: AO-06-ES2194-100
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