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Antibody Product Overview
| ELK.No | ES2284 |
| Product name | Epsin 1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | EPN1; Epsin-1; EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 29924 |
| Human Swiss-Prot | Q9Y6I3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Epsin 1 |
| Fields | >>Endocytosis |
| Gene name | EPN1 |
| Protein name | Epsin-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13854 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q80VP1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 117277 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O88339 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from Epsin 1 . at AA range: 140-220 |
| Specificity | Epsin 1 Polyclonal Antibody detects endogenous levels of Epsin 1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016], |
| Function | domain:The DPW repeat domain is involved in AP2A2 and clathrin binding.,domain:The NPF repeat domain is involved in EPS15 binding.,function:Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.,online information:The bubble's bend -Issue 42 of January 2004,PTM:Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.,PTM:Ubiquitinated.,similarity:Belongs to the epsin family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,subcellular location:Associated with the cytoplasmic membrane |
| Subcellular location | Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus . Membrane, clathrin-coated pit . Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). . |
| Expression | Brain,Epithelium,Mammary gland, |
Additional Images
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Western Blot analysis of various cells using Epsin 1 Polyclonal Antibody diluted at 1:1000
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Western Blot analysis of MOuse-brain cells using Epsin 1 Polyclonal Antibody diluted at 1:1000
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: AO-06-ES2284-50
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