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Antibody Product Overview
| ELK.No | ES2375 |
| Product name | FRP-2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | SFRP2; FRP2; SARP1; FKSG12; Secreted frizzled-related protein 2; FRP-2; sFRP-2; Secreted apoptosis-related protein 1; SARP-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6423 |
| Human Swiss-Prot | Q96HF1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FRP-2 |
| Fields | >>Wnt signaling pathway |
| Gene name | SFRP2 |
| Protein name | Secreted frizzled-related protein 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20319 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P97299 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SFRP2. AA range:119-168 |
| Specificity | FRP-2 Polyclonal Antibody detects endogenous levels of FRP-2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008], |
| Function | domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,tissue specificity:Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon., |
| Subcellular location | Secreted . |
| Expression | Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. |
Additional Images
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Western Blot analysis of various cells using FRP-2 Polyclonal Antibody diluted at 1:500
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Western Blot analysis of HuvEc cells using FRP-2 Polyclonal Antibody diluted at 1:500
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Western blot analysis of lysates from HeLa, COLO, and HUVEC cells, using SFRP2 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES2375-50
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