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Antibody Product Overview
| ELK.No | ES2397 |
| Product name | GAP1-InsP4 BP rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | RASA3; Ras GTPase-activating protein 3; GAP1(IP4BP); Ins P4-binding protein |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 22821 |
| Human Swiss-Prot | Q14644 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GAP1-InsP4 BP |
| Fields | >>Ras signaling pathway |
| Gene name | RASA3 |
| Protein name | Ras GTPase-activating protein 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19414 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60790 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29372 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9QYJ2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RASA3. AA range:247-296 |
| Specificity | GAP1-InsP4 BP Polyclonal Antibody detects endogenous levels of GAP1-InsP4 BP protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 95kD |
| Background | This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
| Function | function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains., |
| Subcellular location | Cell membrane. |
| Expression | Blood,Brain,Peripheral blood,Platelet,Testis, |
Additional Images
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Western Blot analysis of various cells using GAP1-InsP4 BP Polyclonal Antibody
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Western blot analysis of RASA3 Antibody. The lane on the right is blocked with the RASA3 peptide.
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Western blot analysis of the lysates from HUVECcells using RASA3 antibody.
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: AO-06-ES2397-100
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