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Antibody Product Overview
| ELK.No | ES2425 |
| Product name | GIPR rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | GIPR; Gastric inhibitory polypeptide receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2696 |
| Human Swiss-Prot | P48546 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GIPR |
| Fields | >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction |
| Gene name | GIPR |
| Protein name | Gastric inhibitory polypeptide receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q0P543 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GIPR. AA range:93-142 |
| Specificity | GIPR Polyclonal Antibody detects endogenous levels of GIPR protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 53kD |
| Background | This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011], |
| Function | function:This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Colon,G-protein coupled receptors,Pancreas, |
Additional Images
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Western Blot analysis of various cells using GIPR Polyclonal Antibody
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Immunofluorescence analysis of MCF7 cells, using GIPR Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using GIPR Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HT-29 cells using GIPR antibody.
: AO-06-ES2425-100
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