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Antibody Product Overview
| ELK.No | ES2431 |
| Product name | GLK rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | MAP4K3; RAB8IPL1; Mitogen-activated protein kinase kinase kinase kinase 3; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8491 |
| Human Swiss-Prot | Q8IVH8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GLK |
| Fields | >>MAPK signaling pathway |
| Gene name | MAP4K3 |
| Protein name | Mitogen-activated protein kinase kinase kinase kinase 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q99JP0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 170920 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q924I2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAP4K3. AA range:10-59 |
| Specificity | GLK Polyclonal Antibody detects endogenous levels of GLK protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 101kD |
| Background | mitogen-activated protein kinase kinase kinase kinase 3(MAP4K3) Homo sapiens This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012], |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation.,tissue specificity:Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver., |
| Subcellular location | intracellular,cytoplasm, |
| Expression | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. |
Additional Images
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Western Blot analysis of various cells using GLK Polyclonal Antibody
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Western blot analysis of lysates from HepG2 and K562 cells, using MAP4K3 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES2431-100
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