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Antibody Product Overview
| ELK.No | ES2433 |
| Product name | Glucagon Receptor rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | GCGR; Glucagon receptor; GL-R |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2642 |
| Human Swiss-Prot | P47871 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Glucagon Receptor |
| Fields | >>Neuroactive ligand-receptor interaction;>>Glucagon signaling pathway |
| Gene name | GCGR |
| Protein name | Glucagon receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14527 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61606 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24953 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P30082 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GLR. AA range:95-144 |
| Specificity | Glucagon Receptor Polyclonal Antibody detects endogenous levels of Glucagon Receptor protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 54kD |
| Background | glucagon receptor(GCGR) Homo sapiens The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010], |
| Function | disease:It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.,function:This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Is rapidly internalized after ligand-binding. . |
| Expression | Liver,Placenta, |
Additional Images
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Western Blot analysis of various cells using Glucagon Receptor Polyclonal Antibody
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Western Blot analysis of COLO205 cells using Glucagon Receptor Polyclonal Antibody
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Immunofluorescence analysis of HeLa cells, using GLR Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from COLO205 cells, using GLR Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2433-50
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