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Antibody Product Overview
| ELK.No | ES2445 |
| Product name | GPR105 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | P2RY14; GPR105; KIAA0001; P2Y purinoceptor 14; P2Y14; G-protein coupled receptor 105; UDP-glucose receptor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9934 |
| Human Swiss-Prot | Q15391 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GPR105 |
| Fields | >>Neuroactive ligand-receptor interaction |
| Gene name | P2RY14 |
| Protein name | P2Y purinoceptor 14 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 140795 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9ESG6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 171108 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O35881 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPR105. AA range:146-195 |
| Specificity | GPR105 Polyclonal Antibody detects endogenous levels of GPR105 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 39kD |
| Background | The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney. |
Additional Images
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Western Blot analysis of various cells using GPR105 Polyclonal Antibody
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Immunofluorescence analysis of MCF7 cells, using GPR105 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from 293, COLO205, and HepG2 cells, using GPR105 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from K562 cells using GPR105 antibody.
: AO-06-ES2445-100
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