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Antibody Product Overview
| ELK.No | ES2552 |
| Product name | hnRNP L rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC;IF;ELISA |
| Other name | HNRNPL; HNRPL; P/OKcl.14; Heterogeneous nuclear ribonucleoprotein L; hnRNP L |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3191 |
| Human Swiss-Prot | P14866 |
| Source | Rabbit |
| Isotype | IgG |
| Target | hnRNP L |
| Fields | |
| Gene name | HNRNPL |
| Protein name | Heterogeneous nuclear ribonucleoprotein L |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 15388 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8R081 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human hnRNP L. AA range:61-110 |
| Specificity | hnRNP L Polyclonal Antibody detects endogenous levels of hnRNP L protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different is |
| Function | function:This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.,PTM:Several isoelectric forms of the L protein are probably the results of post-translational modifications.,similarity:Contains 3 RRM (RNA recognition motif) domains., |
| Subcellular location | Nucleus, nucleoplasm . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. . |
| Expression | Brain,Cajal-Retzius cell,Fetal brain cortex,Keratinocyte,Pa |
Additional Images
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Western Blot analysis of various cells using hnRNP L Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western Blot analysis of HuvEc cells using hnRNP L Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Immunofluorescence analysis of HeLa cells, using hnRNP L Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using hnRNP L Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES2552-50
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