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Antibody Product Overview
| ELK.No | ES2616 |
| Product name | IL-3Rβ rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | CSF2RB; IL3RB; IL5RB; Cytokine receptor common subunit beta; CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD antigen CD131 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1439 |
| Human Swiss-Prot | P32927 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IL-3Rβ |
| Fields | >>Cytokine-cytokine receptor interaction;>>Apoptosis;>>JAK-STAT signaling pathway;>>Pathways in cancer |
| Gene name | CSF2RB |
| Protein name | Cytokine receptor common subunit beta |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12983 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P26955 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL-3R beta. AA range:559-608 |
| Specificity | IL-3Rβ Polyclonal Antibody detects endogenous levels of IL-3Rβ protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 125kD |
| Background | The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors., |
| Subcellular location | Membrane; Single-pass type I membrane protein. |
| Expression | Placenta, |
Additional Images
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Western Blot analysis of various cells using IL-3Rβ Polyclonal Antibody
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Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using IL-3R beta Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from Raw264.7 cells, treated with G-CSF 25ng/ml 15', using IL-3R beta Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2616-50
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