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Antibody Product Overview
| ELK.No | ES2727 |
| Product name | LTB4DH rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | PTGR1; LTB4DH; Prostaglandin reductase 1; PRG-1; 15-oxoprostaglandin 13-reductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 22949 |
| Human Swiss-Prot | Q14914 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LTB4DH |
| Fields | |
| Gene name | PTGR1 |
| Protein name | Prostaglandin reductase 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q91YR9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PTGR1. AA range:75-124 |
| Specificity | LTB4DH Polyclonal Antibody detects endogenous levels of LTB4DH protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 36kD |
| Background | This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009], |
| Function | catalytic activity:11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.,catalytic activity:n-alkanal + NAD(P)(+) = alk-2-enal + NAD(P)H.,function:Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.,similarity:Belongs to the NADP-dependent oxidoreductase L4BD family.,subunit:Monomer or homodimer.,tissue specificity:High expression in the kidney, liver, and intestine but not in leukocytes., |
| Subcellular location | Cytoplasm . |
| Expression | High expression in the kidney, liver, and intestine but not in leukocytes. |
Additional Images
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Western Blot analysis of various cells using LTB4DH Polyclonal Antibody
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Western blot analysis of lysates from HT-29 cells, using PTGR1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from 293 cells using PTGR1 antibody.
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: AO-06-ES2727-100
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