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Antibody Product Overview
| ELK.No | ES2737 |
| Product name | mAChR M4 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | CHRM4; Muscarinic acetylcholine receptor M4 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1132 |
| Human Swiss-Prot | P08173 |
| Source | Rabbit |
| Isotype | IgG |
| Target | mAChR M4 |
| Fields | >>Neuroactive ligand-receptor interaction;>>Cholinergic synapse;>>Regulation of actin cytoskeleton |
| Gene name | CHRM4 |
| Protein name | Muscarinic acetylcholine receptor M4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12672 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P32211 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25111 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P08485 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHRM4. AA range:236-285 |
| Specificity | mAChR M4 Polyclonal Antibody detects endogenous levels of mAChR M4 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 53kD |
| Background | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008], |
| Function | function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Expression | Brain, |
Additional Images
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Western Blot analysis of various cells using mAChR M4 Polyclonal Antibody
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Immunofluorescence analysis of LOVO cells, using CHRM4 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES2737-100
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