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Antibody Product Overview
| ELK.No | ES2757 |
| Product name | MC2-R rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA;IHC |
| Other name | MC2R; ACTHR; Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4158 |
| Human Swiss-Prot | Q01718 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MC2-R |
| Fields | >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>Cushing syndrome |
| Gene name | MC2R |
| Protein name | Adrenocorticotropic hormone receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17200 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q64326 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACTHR. AA range:248-297 |
| Specificity | MC2-R Polyclonal Antibody detects endogenous levels of MC2-R protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 34kD |
| Background | MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014], |
| Function | disease:Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.,function:Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FALP/MRAP.,tissue specificity:Melanocytes and corticoadrenal tissue., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Melanocytes and corticoadrenal tissue. |
Additional Images
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Western Blot analysis of various cells using MC2-R Polyclonal Antibody
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Immunofluorescence analysis of MCF7 cells, using ACTHR Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HeLa cells, using ACTHR Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from COLO205 cells using ACTHR antibody.
: AO-06-ES2757-100
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