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Antibody Product Overview
| ELK.No | ES2765 |
| Product name | Med18 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | MED18; Mediator of RNA polymerase II transcription subunit 18; Mediator complex subunit 18; p28b |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 54797 |
| Human Swiss-Prot | Q9BUE0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Med18 |
| Fields | |
| Gene name | MED18 |
| Protein name | Mediator of RNA polymerase II transcription subunit 18 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 67219 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CZ82 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MED18. AA range:70-119 |
| Specificity | Med18 Polyclonal Antibody detects endogenous levels of Med18 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 24kD |
| Background | MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008], |
| Function | function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.,similarity:Belongs to the Mediator complex subunit 18 family.,subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 su |
| Subcellular location | Nucleus . |
| Expression | Colon,Lymphoma,Uterus, |
Additional Images
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Western Blot analysis of various cells using Med18 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of lysates from COLO and Jurkat cells, using MED18 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES2765-100
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