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Antibody Product Overview
| ELK.No | ES2861 |
| Product name | MST-3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | STK24; MST3; STK3; Serine/threonine-protein kinase 24; Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8428 |
| Human Swiss-Prot | Q9Y6E0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MST3 |
| Fields | |
| Gene name | STK24 |
| Protein name | Serine/threonine-protein kinase 24 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 223255 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99KH8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 361092 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | B0LT89 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human STK24. AA range:319-368 |
| Specificity | MST-3 Polyclonal Antibody detects endogenous levels of MST-3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 50kD |
| Background | This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013], |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Manganese. Only isoform A requires manganese.,function:Protein kinase that act on both serine and threonine residues.,PTM:Autophosphorylated. Isoform B is activated by phosphorylation by PKA.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex., |
| Subcellular location | Cytoplasm. Nucleus. Membrane. The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane. |
| Expression | Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. |
Additional Images
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Western Blot analysis of various cells using MST-3 Polyclonal Antibody diluted at 1:1000
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using STK24 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from COLO cells, using STK24 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from COLO205 cells using STK24 antibody.
: AO-06-ES2861-100
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