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Antibody Product Overview
| ELK.No | ES2863 |
| Product name | MTHFR rabbit pAb |
| Reactivity | Human;Mouse;Monkey |
| Applications | WB;ELISA;IHC |
| Other name | MTHFR; Methylenetetrahydrofolate reductase |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4524 |
| Human Swiss-Prot | P42898 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MTHFR |
| Fields | >>One carbon pool by folate;>>Metabolic pathways;>>Antifolate resistance |
| Gene name | MTHFR |
| Protein name | Methylenetetrahydrofolate reductase |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17769 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9WU20 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MTHFR. AA range:314-363 |
| Specificity | MTHFR Polyclonal Antibody detects endogenous levels of MTHFR protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 75kD |
| Background | The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009], |
| Function | catalytic activity:5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.,cofactor:FAD.,disease:Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.,disease:Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.,disease:Defects in MTHFR may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leadin |
| Subcellular location | cytosol,synapse, |
| Expression | Brain,Liver,Lung, |
Additional Images
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Western Blot analysis of various cells using MTHFR Polyclonal Antibody
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Western blot analysis of lysate from COLO205 cells treated with Forskolin, using MTHFR antibody.
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Immunohistochemical analysis of paraffin-embedded human oophoroma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES2863-50
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