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Antibody Product Overview
| ELK.No | ES2889 |
| Product name | Na+ CP type IIβ rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | SCN2B; Sodium channel subunit beta-2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6327 |
| Human Swiss-Prot | O60939 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SCN2B |
| Fields | |
| Gene name | SCN2B |
| Protein name | Sodium channel subunit beta-2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 72821 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q56A07 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25349 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P54900 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SCN2B. AA range:71-120 |
| Specificity | Na+ CP type IIβ Polyclonal Antibody detects endogenous levels of Na+ CP type IIβ protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 24kD |
| Background | The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015], |
| Function | function:Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR.,tissue specificity:Brain specific., |
| Subcellular location | Membrane; Single-pass type I membrane protein. |
| Expression | Brain specific. |
Additional Images
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Western Blot analysis of various cells using Na+ CP type IIβ Polyclonal Antibody
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Western blot analysis of SCN2B Antibody. The lane on the right is blocked with the SCN2B peptide.
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Western blot analysis of the lysates from HepG2 cells using SCN2B antibody.
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Immunohistochemical analysis of paraffin-embedded human lung cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES2889-100
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