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Antibody Product Overview
| ELK.No | ES2899 |
| Product name | NBK rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | BIK; NBK; Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 638 |
| Human Swiss-Prot | Q13323 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NBK |
| Fields | >>Endocrine resistance |
| Gene name | BIK |
| Protein name | Bcl-2-interacting killer |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O70337 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BIK. AA range:18-67 |
| Specificity | NBK Polyclonal Antibody detects endogenous levels of NBK protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30 25kD |
| Background | The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011], |
| Function | domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.,subcellular location:Around the nuclear envelope, and in cytoplasmic membranes., |
| Subcellular location | Endomembrane system; Single-pass membrane protein. Mitochondrion membrane ; Single-pass membrane protein . Around the nuclear envelope, and in cytoplasmic membranes. |
| Expression | B-cell,Lymph,Lymphoid, |
Additional Images
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Western Blot analysis of various cells using NBK Polyclonal Antibody diluted at 1:500
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Immunofluorescence analysis of HUVEC cells, using BIK Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using BIK Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HUVEC/COLO205, using BIK Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2899-50
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