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Antibody Product Overview
| ELK.No | ES2964 |
| Product name | NK-3R rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | TACR3; NK3R; TAC3R; Neuromedin-K receptor; NKR; NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6870 |
| Human Swiss-Prot | P29371 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NK-3R |
| Fields | >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction |
| Gene name | TACR3 |
| Protein name | Neuromedin-K receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 21338 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P47937 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24808 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P16177 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NK3R. AA range:401-450 |
| Specificity | NK-3R Polyclonal Antibody detects endogenous levels of NK-3R protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 52kD |
| Background | This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008], |
| Function | function:This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.,miscellaneous:The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.,PTM:The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Brain,G-protein coupled receptors,PCR rescued clones,Placenta, |
Additional Images
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Western Blot analysis of various cells using NK-3R Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western Blot analysis of COLO205 cells using NK-3R Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Immunofluorescence analysis of A549 cells, using NK3R Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from COLO205 cells, using NK3R Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2964-100
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