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Antibody Product Overview
| ELK.No | ES2988 |
| Product name | Nrl rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | NRL; D14S46E; Neural retina-specific leucine zipper protein; NRL |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4901 |
| Human Swiss-Prot | P54845 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Nrl |
| Fields | |
| Gene name | NRL |
| Protein name | Neural retina-specific leucine zipper protein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18185 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P54846 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NRL. AA range:19-68 |
| Specificity | Nrl Polyclonal Antibody detects endogenous levels of Nrl protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 25kD |
| Background | This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27) [MIM:162080]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant.,function:Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Interacts with FIZ1. This interaction represses transactivation.,tissue specificity:Neural retina., |
| Subcellular location | Cytoplasm . Nucleus . |
| Expression | Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108). |
Additional Images
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Western Blot analysis of various cells using Nrl Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of NRL Antibody. The lane on the right is blocked with the NRL peptide.
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Western blot analysis of the lysates from HUVECcells using NRL antibody.
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: AO-06-ES2988-100
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