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Antibody Product Overview
| ELK.No | ES3253 |
| Product name | PPP2R3C rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | PPP2R3C; C14orf10; G5PR; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 55012 |
| Human Swiss-Prot | Q969Q6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PPP2R3C |
| Fields | >>mRNA surveillance pathway;>>Sphingolipid signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Dopaminergic synapse;>>Human papillomavirus infection |
| Gene name | PPP2R3C |
| Protein name | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 59032 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9JK24 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 362739 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q6AXZ3 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPP2R3C. AA range:165-214 |
| Specificity | PPP2R3C Polyclonal Antibody detects endogenous levels of PPP2R3C protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 55kD |
| Background | This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015], |
| Function | developmental stage:Expressed in fetal brain.,function:May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells.,similarity:Contains 2 EF-hand domains.,subcellular location:Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.,subunit:Interacts with MCM3AP/GANP (By similarity). Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A.,tissue specificity:Ubiquitously expressed in brain and other tissues., |
| Subcellular location | Nucleus . Cytoplasm . Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. . |
| Expression | Ubiquitously expressed in brain and other tissues. |
Additional Images
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Western Blot analysis of various cells using PPP2R3C Polyclonal Antibody
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Western blot analysis of PPP2R3C Antibody. The lane on the right is blocked with the PPP2R3C peptide.
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Western blot analysis of the lysates from HepG2 cells using PPP2R3C antibody.
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES3253-100
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