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Ribosomal Protein S3 rabbit pAb
AO-06-ES3373-100
Antibody Product Overview
| ELK.No | ES3373 |
| Product name | Ribosomal Protein S3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | RPS3; OK/SW-cl.26; 40S ribosomal protein S3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6188 |
| Human Swiss-Prot | P23396 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Ribosomal Protein S3 |
| Fields | >>Ribosome;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Coronavirus disease - COVID-19 |
| Gene name | RPS3 |
| Protein name | 40S ribosomal protein S3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 27050 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P62908 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 140654 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P62909 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RPS3. AA range:171-220 |
| Specificity | Ribosomal Protein S3 Polyclonal Antibody detects endogenous levels of Ribosomal Protein S3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and |
| Function | similarity:Belongs to the ribosomal protein S3P family.,similarity:Contains 1 KH type-2 domain., |
| Subcellular location | Cytoplasm . Nucleus . Nucleus, nucleolus . Mitochondrion inner membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, spindle . In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). . |
| Expression | Adrenal cortex,Cervix carcinoma,Colon adenocarcinoma,Epithelium,Liver,Lymph,Pituita |
Additional Images
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Western Blot analysis of various cells using Ribosomal Protein S3 Polyclonal Antibody
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Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using RPS3 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HepG2 cells, using RPS3 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from RAW264.7cells using RPS3 antibody.
: AO-06-ES3373-100
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