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Antibody Product Overview
| ELK.No | ES3453 |
| Product name | SLC6A8 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC |
| Other name | SLC6A8; Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6535 |
| Human Swiss-Prot | P48029 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SLC6A8 |
| Fields | |
| Gene name | SLC6A8 |
| Protein name | Sodium- and chloride-dependent creatine transporter 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 102857 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8VBW1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 50690 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P28570 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC6A8. AA range:581-630 |
| Specificity | SLC6A8 Polyclonal Antibody detects endogenous levels of SLC6A8 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 70kD |
| Background | The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008], |
| Function | disease:Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome [MIM:300352]. X-linked creatine deficiency syndrome causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia.,function:Required for the uptake of creatine in muscles and brain.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate., |
| Subcellular location | Membrane; Multi-pass membrane protein. |
| Expression | Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate. |
Additional Images
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Western Blot analysis of various cells using SLC6A8 Polyclonal Antibody
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Western blot analysis of SLC6A8 Antibody. The lane on the right is blocked with the SLC6A8 peptide.
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Western blot analysis of the lysates from HUVECcells using SLC6A8 antibody.
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES3453-100
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