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Antibody Product Overview
| ELK.No | ES3522 |
| Product name | StIp1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC |
| Other name | ELP2; STATIP1; Elongator complex protein 2; ELP2; SHINC-2; STAT3-interacting protein 1; StIP1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 55250 |
| Human Swiss-Prot | Q6IA86 |
| Source | Rabbit |
| Isotype | IgG |
| Target | StIp1 |
| Fields | |
| Gene name | ELP2 |
| Protein name | Elongator complex protein 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q91WG4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ELP2. AA range:771-820 |
| Specificity | StIp1 Polyclonal Antibody detects endogenous levels of StIp1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 93kD |
| Background | The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016], |
| Function | function:Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.,function:Regulates the ligand-dependent activation of STAT3.,similarity:Belongs to the WD repeat ELP2 family.,similarity:Contains 14 WD repeats.,subunit:Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with STAT3 and JAKs., |
| Subcellular location | Cytoplasm . Nucleus . |
| Expression | Hematopoietic,Liver,Ovary,Uterus, |
Additional Images
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Western Blot analysis of various cells using StIp1 Polyclonal Antibody
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Western blot analysis of lysates from HT-29 cells, using ELP2 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES3522-50
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