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Antibody Product Overview
| ELK.No | ES3665 |
| Product name | UBE2D2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | UBE2D2; UBC4; UBC5B; UBCH4; UBCH5B; Ubiquitin-conjugating enzyme E2 D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 7322 |
| Human Swiss-Prot | P62837 |
| Source | Rabbit |
| Isotype | IgG |
| Target | UBE2D2 |
| Fields | >>Ubiquitin mediated proteolysis;>>Protein processing in endoplasmic reticulum;>>Shigellosis |
| Gene name | UBE2D2 |
| Protein name | Ubiquitin-conjugating enzyme E2 D2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56550 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P62838 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 641452 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P62839 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human UBE2D2. AA range:98-147 |
| Specificity | UBE2D2 Polyclonal Antibody detects endogenous levels of UBE2D2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 17kD |
| Background | Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013], |
| Function | catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3 ubiquitin-protein ligase PJA2., |
| Subcellular location | ubiquitin ligase complex,nucleoplasm,cytosol,protein complex,extracellular exosome, |
| Expression | Brain,Cajal-Retzius cell,Testis, |
Additional Images
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Western Blot analysis of various cells using UBE2D2 Polyclonal Antibody diluted at 1:2000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western blot analysis of the lysates from K562 cells using UBE2D2 antibody.
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: AO-06-ES3665-100
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