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Antibody Product Overview
| ELK.No | ES3764 |
| Product name | GDI-1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | GDI1; GDIL; OPHN2; RABGDIA; XAP4; Rab GDP dissociation inhibitor alpha; Rab GDI alpha; Guanosine diphosphate dissociation inhibitor 1; GDI-1; Oligophrenin-2; Protein XAP-4 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2664 |
| Human Swiss-Prot | P31150 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GDI-1 |
| Fields | |
| Gene name | GDI1 |
| Protein name | Rab GDP dissociation inhibitor alpha |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14567 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P50396 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25183 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P50398 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GDI-1. AA range:394-443 |
| Specificity | GDI-1 Polyclonal Antibody detects endogenous levels of GDI-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 50kD |
| Background | GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in GDI1 are the cause of mental retardation X-linked type 41 (MRX41) [MIM:300104]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,disease:Defects in GDI1 are the cause of mental retardation X-linked type 48 (MRX48) [MIM:300104]; also known as MRX3.,function:Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rab GDI family.,tissue specificity:Brain; predominant in neural and sensory tissues., |
| Subcellular location | Cytoplasm . Golgi apparatus, trans-Golgi network . |
| Expression | Brain; predominant in neural and sensory tissues. |
Additional Images
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Western Blot analysis of extracts from K562 cells, using GDI-1 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western blot analysis of lysates from brain tissue, using GDI-1 antibody.
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: AO-06-ES3764-50
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