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Antibody Product Overview
| ELK.No | ES3813 |
| Product name | HNF-1β rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | HNF1B; TCF2; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6928/6928 |
| Human Swiss-Prot | P35680 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HNF-1β |
| Fields | >>Maturity onset diabetes of the young |
| Gene name | HNF1B |
| Protein name | Hepatocyte nuclear factor 1-beta |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 21410 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P27889 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25640 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P23899 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from the N-terminal region of human HNF-1β. |
| Specificity | HNF-1β Polyclonal Antibody detects endogenous levels of HNF-1β protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009], |
| Function | disease:A genetic variation in HNF1B is associated with susceptibility to hereditary prostate cancer type 11 (HPC11) [MIM:611955].,disease:Defects in HNF1B are a cause of Muellerian aplasia [MIM:158330]. In a Norwegian family with a novel syndrome of mild diabetes and severe non-diabetic renal disease, Muellerian aplasia expressed as vaginal aplasia and rudimentary uterus, were found in 2 females. These findings suggest that a broader spectrum of clinical symptoms may be associated with defects in HNF1B than previously recognized.,disease:Defects in HNF1B are the cause of maturity-onset diabetes of the young type 5 (MODY5) [MIM:604284]. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.,disease:Defects in HNF1B are the cause of renal cysts and diabetes |
| Subcellular location | Nucleus. |
| Expression | Colon,Liver,Thalamus, |
Additional Images
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Western Blot analysis of extracts from Jurkat cells, using HNF-1β Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES3813-50
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