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Antibody Product Overview
| ELK.No | ES3852 |
| Product name | Contactin 1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CNTN1; Contactin-1; Glycoprotein gp135; Neural cell surface protein F3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1272 |
| Human Swiss-Prot | Q12860 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Contactin 1 |
| Fields | >>Cell adhesion molecules |
| Gene name | CNTN1 |
| Protein name | Contactin-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12805 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P12960 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 117258 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63198 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Contactin 1. |
| Specificity | Contactin 1 Polyclonal Antibody detects endogenous levels of Contactin 1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 113kD |
| Background | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
| Function | disease:Defects in CNTN1 are the cause of Compton-North congenital myopathy [MIM:612540]. Compton-North congenital myopathy is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.,function:Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucl |
| Subcellular location | [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. |
| Expression | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. |
Additional Images
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Western Blot analysis of mouse brain cells using Contactin 1 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES3852-100
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