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Antibody Product Overview
| ELK.No | ES3884 |
| Product name | BNIP-3 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | BNIP3; NIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 664 |
| Human Swiss-Prot | Q12983 |
| Source | Rabbit |
| Isotype | IgG |
| Target | BNIP-3 |
| Fields | >>FoxO signaling pathway;>>Mitophagy - animal;>>Autophagy - animal;>>Shigellosis;>>Legionellosis |
| Gene name | BNIP3 |
| Protein name | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O55003 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human BNIP3. AA range:71-120 |
| Specificity | BNIP-3 Polyclonal Antibody detects endogenous levels of BNIP-3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 22kD |
| Background | This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014], |
| Function | function:Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.,similarity:Belongs to the NIP3 family.,subcellular location:Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope.,subunit:Homodimer. Binds to BCL2. Interacts with BNIP3L. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1., |
| Subcellular location | Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane. |
| Expression | B-cell,Brain,Cerebellum,Kidney,Testis, |
Additional Images
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Western Blot analysis of mouse eye cells using BNIP-3 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
: AO-06-ES3884-100
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