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Antibody Product Overview
| ELK.No | ES3918 |
| Product name | CUL-4B rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | CUL4B; KIAA0695; Cullin-4B; CUL-4B |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 8450 |
| Human Swiss-Prot | Q13620 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CUL4B |
| Fields | >>Nucleotide excision repair;>>Ubiquitin mediated proteolysis;>>Human immunodeficiency virus 1 infection |
| Gene name | CUL4B |
| Protein name | Cullin-4B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 72584 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | A2A432 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CUL4B. AA range:711-760 |
| Specificity | CUL-4B Polyclonal Antibody detects endogenous levels of CUL-4B protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 110kD |
| Background | This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in CUL4B are the cause of Cabezas X-linked mental retardation syndrome (MRXC) [MIM:300354]; also called X-linked mental retardation with short stature small testes muscle wasting and tremor. MRXC patients show delayed puberty, hypogonadism, relative macrocephaly, moderate short stature, central obesity, unprovoked aggressive outbursts, fine intention tremor, pes cavus, and abnormalities of the toes.,disease:Defects in CUL4B are the cause of X-linked mental retardation-hypotonic facies syndrome type 2 (MRXHF2) [MIM:300639]; also called Smith-Fineman-Myers syndrome type 2 or SFM2. The distinguishing manifestations of MRXHF2 are relative microcephaly, short stature, hypertelorism, macrostomia, patulous lips, difficulty in speech, micrognathia, short thumbs and little fingers with adduction, hypotonia at age less than 10 years, and later hypertonia, restlessness, and seizures |
| Subcellular location | Nucleus . |
| Expression | Brain,Fetal liver,Testis, |
Additional Images
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Western Blot analysis of mouse liver, mouse kidney, mouse heart cells using CUL-4B Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100
: AO-06-ES3918-100
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