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Antibody Product Overview
| ELK.No | ES3976 |
| Product name | CD32-B/C rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | FCGR2B; CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD32; FCGR2C; CD32; FCG2; IGFR2;Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD32 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2213 |
| Human Swiss-Prot | P31994 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD32 |
| Fields | >>Phagosome;>>Osteoclast differentiation;>>B cell receptor signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Measles |
| Gene name | FCGR2B/FCGR2C |
| Protein name | Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human FCGR2B/C. AA range:141-190 |
| Specificity | CD32-B/C Polyclonal Antibody detects endogenous levels of CD32-B/C protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 35kD |
| Background | Low affinity immunoglobulin gamma Fc region receptor II-b/Low affinity immunoglobulin gamma Fc region receptor II-c encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. |
| Function | immune response, |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. |
| Expression | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
Additional Images
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Western Blot analysis of K562 cells using CD32-B/C Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES3976-50
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